| Team name | Location | League | Level | Status |
|---|---|---|---|---|
| Chicago Pythons | Chicago, Illinois | Continental Indoor Football League | professional | defunct |
| CT Pythons | , Connecticut | Premier Arena Soccer League | amateur | defunct |
| Paideia Pythons | Atlanta, Georgia | high school | active | |
| Panorama Pythons | Panorama City, California | high school | active | |
| Pelham Pythons | Pelham, New Hampshire | high school | active | |
| Portland Pythons | Portland, Oregon | World Indoor Soccer League | professional | defunct |